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In 1989 Dave Bricker set off across the Gulf Stream in a small sailboat with $30 in his pocket. His voyages aboard The Blue Monk through the Bahamas and across the Atlantic to Gibraltar are recounted in vivid prose. The Blue Monk is a journey of self-discovery set in a world of saturated colors, remarkable people, hazardous reefs, and transcendent beauty. Bricker chronicles a little-known fragment of Miami's history and encourages us all to embrace a world of power and magic that lies only a few steps off the sidewalk.

The Blue Monk is cloth bound with an attractive modernist dust jacket, gold foil stamped, and typeset to 1920s "hot metal" standards. Big publishers use small type, tight leading (line spacing), and narrow margins to save ink, paper, and shipping costs on huge print runs. This book demonstrates how self-publishers can exceed industry standards to produce elegant, comfortable to read books.

The Blue Monk received a 2014 IPPY Award for "Excellence in Independent Publishing."

• Sales Rank: #3009368 in Books
• Published on: 2014-01-31
• Original language: English
• Number of items: 1
• Dimensions: 9.02" h x 1.13" w x 5.98" l, 1.77 pounds
• Binding: Hardcover
• 444 pages

From the Author
In 1983, when I was 18-years old, I encountered a com�mu�nity of eccen�tric sailors who lived in a secret anchor�age on the far side of the spoil islands a quarter-mile from Miami City Hall. What I found there inspired me and chal�lenged me to expand my per�spec�tives. Though the Dinner Key Anchorage was often dis�missed as a com�mu�nity of "dere�licts, bums, winos and thieves," I found instead a group of artic�u�late, capa�ble, inno�v�a�tive, edu�cated, and highly skilled peo�ple who took me in and lit�er�ally 'taught me the ropes.' Many of them trav�eled the world, depend�ing on lit�tle but good for�tune and deter�mi�na�tion.

At 23, while working on a jazz gui�tar degree, I bought an old 26-foot sail�boat and named her The Blue Monk after the tune by pianist, Thelonious Monk. Six months after grad�u�at�ing, I took off with $30 in my pocket for a series of adven�tures that took me through the Bahamas and even�tu�ally across the Atlantic to Gibraltar.

On the sur�face, The Blue Monk is a mem�oir that recounts how I came to love sail�ing, joined a unique com�mu�nity of mis�un�der�stood peo�ple, and sailed away to enjoy a life of adven�ture. The book also pro�vides an account of a spe�cial slice of Miami his�tory that would oth�er�wise remain unrecorded. But The Blue Monk is not really about me; who wants to read a book by an author who can write about him�self for hun�dreds of pages? The Blue Monk is about some�thing much larger; I am but the nar�ra�tor. My expe�ri�ences sail�ing alone on a small boat were beau�ti�ful and some�times ter�ri�fy�ing. Often, they were an odd com�bi�na�tion of both. The Blue Monk tells of an encounter with a remark�able world that lies just beyond the hori�zon and deep within each of us. The Blue Monk is rich life experience translated into prose, a vehicle that transports the reader there and then.

From the Inside Flap
In 1989 Dave Bricker set off across the Gulf Stream in a small sailboat with $30 in his pocket. His voyages aboard The Blue Monk through the Bahamas and across the Atlantic to Gibraltar are recounted in vivid prose. The Blue Monk is a journey of self-discovery set in a world of saturated colors, remarkable people, hazardous reefs, and transcendent beauty. Bricker chronicles a little-known fragment of Miami's history and encourages us all to embrace a world of power and magic that lies only a few steps off the sidewalk.

About the Author
Dave Bricker, MFA is the author of The Dance, Waves, Currents, and The One Hour Guide to Self-Publishing. He runs a marketing and design studio in Miami, Florida, plays guitar in a 1930s acoustic swing band, and created the ™ eBook Publishing Platform.

Most helpful customer reviews

3 of 3 people found the following review helpful.
A great sailor's odyssey
By Lee A. Bricker
Full disclosure here… I’m Dave Bricker’s Dad, and I’m recommending that you read “The Blue Monk.” I, of course, got to watch Dave grow up, proceeding early towards goals his mom and I couldn’t understand. Never a top student, he majored in Jazz in college, and became a first-rate guitarist. While his mom and I despaired of his career choices, such as they were, he gravitated to a community of what we saw as a motley collection of misfits in Miami’s Coconut Grove anchorage, where, inexplicably, he found himself at home. I derisively called him a “street person of the sea,” as, to my eye, despite his expertise with computers, he floundered uselessly around, having somehow learned to survive on 30 cents a month out there on the water. I know better now.

The Blue Monk tells the story, which I read with page-turning fascination. It turns out that this kid of mine, now nearly 50, has meticulously and gorgeously recorded a marvelous odyssey of the sea. As you read, you’ll alternately be drenched by spray, swept into realms of great joy and calm, occasionally run aground in strange places, sometimes made queasy by motions of the craft on choppy and uncertain seas, and will experience, through his powerful descriptive talent, the vastness of the dark, starry night skies, remote beaches, and the total range of things that can happen to an expertly piloted small sailboat alone out on an unforgiving ocean. The reader gets to meet many of the “characters” in the Anchorage, who mostly turn out to be honorable and fascinating, if often non-conforming, folks. You experience the Abacos, Miami Beach, Gibralter, the violent “horizontal Niagara” of Hurricane Andrew, the immense open ocean, and a host of other places, all described with (who would have guessed?) a great storyteller’s keen eye and a true gift for language.

You really should read this book!

Lee Bricker

3 of 3 people found the following review helpful.
To follow a nature
By Mike
To step from the normal walk of life and stretch out to see where the unknown leads is admirable. It's not for everyone to do, but Dave's tales are an inspiration for anyone who long's for adventure; whether they desire the tangible act, or an intangible sense of it.

The characteristics of life under sail are almost indescribable unless you've lived it. Dave's tales brought me back to anchorages and passages with a breeze, and gale, in my face, and a taste of salt in the air - desire for the blue water returned. Aside from the comforts and amenities provided with a large bankroll, the only limit to life on a boat is land. Dave details the qualities, challenges, and character of that life with blunt, humorous, and vivid descriptions of adventure and encounters for all to enjoy.

We all have a tale to share, and I was captivated by The Blue Monk's.

3 of 3 people found the following review helpful.
Loved this account of the Dinner Key Anchorage life and sailing!
By genevieve jacobs
Great reading and a gem of cultural anthropology, rollicking good sailor tales, and a cast of characters that would make Steinbeck proud. Fresh and clean in style with fully footnoted explanations of sailing terminology keeps the pace brisk and vivid for any reader to go seafaring and experience a vanishing epoch of life at anchor and " under weigh".

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[D390.Ebook] Ebook Download The Trespasser: A Novel, by Tana French

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New York Times bestselling author Tana French is “required reading for anyone who appreciates tough, unflinching intelligence and ingenious plotting” (The New York Times). She “inspires cultic devotion in readers . . . (The New Yorker) and is “the most important crime novelist to emerge in the past 10 years” (Washington Post).

“Atmospheric and unputdownable.” –�People�

In bestselling Tana French’s newest “tour de force,”* being on the Murder squad is nothing like Detective Antoinette Conway dreamed it would be. Her partner, Stephen Moran, is the only person who seems glad she’s there. The rest of her working life is a stream of thankless cases, vicious pranks, and harassment. Antoinette is savagely tough, but she’s getting close to the breaking point.
�
Their new case looks like yet another by-the-numbers lovers’ quarrel gone bad. Aislinn Murray is blond, pretty, groomed to a shine, and dead in her catalogue-perfect living room, next to a table set for a romantic dinner. There’s nothing unusual about her—except that Antoinette’s seen her somewhere before.
�
And that her death won’t stay in its neat by-numbers box. Other detectives are trying to push Antoinette and Steve into arresting Aislinn’s boyfriend, fast. There’s a shadowy figure at the end of Antoinette's road. Aislinn's friend is hinting that she knew Aislinn was in danger. And everything they find out about Aislinn takes her further from the glossy, passive doll she seemed to be.
�
Antoinette knows the harassment has turned her paranoid, but she can’t tell just how far gone she is. Is this case another step in the campaign to force her off the squad, or are there darker currents flowing beneath its polished surface?

• Sales Rank: #572 in Books
• Published on: 2016-10-04
• Released on: 2016-10-04
• Original language: English
• Number of items: 1
• Dimensions: 9.31" h x 1.38" w x 6.31" l, 1.55 pounds
• Binding: Hardcover
• 464 pages

Amazon.com Review
An Amazon Best Book of October 2016: Detectives Steve Moran and Antoinette Conway are now partners on the Murder Squad. They’ve been handed a case that at first looks like every other low-energy domestic they’ve ever been given--but during a routine interview, the murdered woman’s friend drops a clue that leads them to suspect this could be bigger than they had imagined. Much bigger. Contentious squad room politics add to their frustration as the detectives are led in conflicting directions by red herrings, dead ends, and warped perceptions. The Trespasser kept me happily discombobulated, guessing at an ending that I didn’t see coming. And that is what makes Tana French one of the best thriller writers out there. --Seira Wilson, The Amazon Book Review

Review
“A tour de force…When you read Ms. French—and she has become required reading for anyone who appreciates tough, unflinching intelligence and ingenious plotting—make only one assumption: All of your initial assumptions are wrong.”
—Janet Maslin, The New York Times*
�
"Tana French is the most interesting, most important crime novelist to emerge in the past 10 years."
—The Washington Post

"[Tana French] inspires cultic devotion in readers…most crime fiction is diverting; French's is consuming."
—The New Yorker

“Atmospheric and unputdownable.”�
—People�

“Thrilling.”
—Buzzfeed
�
"A fierce examination of the chasm between how women choose to present themselves before the world and the more complicated truth underneath--and not to mention a total page-turner."
—Harper's Bazaar

“Beautifully crafted . . . may be her best yet.”�
—Entertainment Weekly

“This is the kind of book you’ll want to dig into with all the lights on.”
—Cup of Jo
�
“There's nothing standard about French's approach to crime fiction, which plays the form much like a jazz musician improvising on a standard. Even when the outlines of the mystery seem familiar…she finds a way to get at enriching themes and powerful emotional truths in fresh and surprising ways.”
—Chicago Tribune
�
“As in all of the author's work, meaning lurks beneath every quip and glance. French not only spins a twisty cop tale, she also encases it in meticulous prose, creating a read that is as elegant as it is dark."
—Associated Press

Praise for Tana French

“To say Tana French is one of the great thriller writers is really too limiting. Rather she’s simply this: a truly great writer.”��
—Gillian Flynn
�
“Terrific—terrifying, amazing, and the prose is incandescent.”
—Stephen King
�
“French is a poet of mood and a master builder of plots.”
�—Maureen Corrigan, The Washington Post
�
“One of the most distinct and exciting new voices in crime writing.”�
—The Wall Street Journal

About the Author
Tana French is also the author of In the Woods, The Likeness, Faithful Place, Broken Harbor and The Secret Place. Her books have won awards including the Edgar, Anthony, Macavity, and Barry awards, the Los Angeles Times Award for Best Mystery/Thriller, and the Irish Book Award for Crime Fiction. She lives in Dublin with her family.

Most helpful customer reviews

58 of 61 people found the following review helpful.
A haunting, beautiful masterpiece.
By Ursula J
The worst part of any Tana French novel, for me, is finishing and coming to the sad realization that it will be another couple years before I am able to experience another novel that leaves the same impression on me. In fact, if anyone has any recommendations as to authors who you feel are reminiscent of French's style of writing, pass them on! I have yet to come across one.

The novel is about partners Antoinette and Stephen who are handed a case that appears easy enough to solve - a lover's tiff gone wrong. While that is the basis of the novel, there are actually several different storylines and so many moving parts to this story that you wonder how it will all weave together. French is particularly adept at writing a story that, while having many twists and turns, never comes at you like a punch in the gut. In fact, as developments occur in the novel, a part of you is left wondering how she managed to pull the wool over your eye enough that it was still a surprise, yet not such a surprise that you had to reread the novel to look for clues as to how you missed it. For this reason, there is no other author in my arsenal that I feel even comes close to her skill level as an author.

Another reason that Tana French is so gifted is because she is always able to create the most complex characters. Her characters are so raw, so deep, that you feel as if you know them. You experience every shift in their case with them; you quicken your breath when they quicken theirs; you need a moment to step away from the novel when things don’t go as planned. You want to reach through the book and tell your characters, BE CAREFUL! when you feel they’re taking unnecessary risks. French is an absolute genius at creating these real life characters whose presence in your life becomes bigger than just fiction.

I have to mention that there is a scene towards the end of the book that I read with a quickening breath and my nerves felt fried. It was as if I was there myself and the suspense leading up to the moment absolutely took my breath away. I’ve only ever experienced such emotions during real life cases I was following on the telly, or documentaries, etc.

Please do yourself a favor and read all of Tana French’s books, if you have not already. Don’t start with this one but begin with her first and then continue. The reason being is because while all of them are amazing, her writing style truly develops as she writes and therefore each one becomes better than the last.

I tried to read this book as slowly as I could, to make it last as long as I could, but I never stood a chance. I would like to thank Tana French for the joy of being able to experience yet another novel that left me speechless.

7 of 7 people found the following review helpful.
Not What I Was Hoping For
By V. Elias
I love Tana French's writing. It doesn't get much better. You have to immerse yourself into her books to understand them, the writing is dense and thick, every word matters. It pains me to say I didn't care for this book. It plodded along for me. I have no problem with a complicated lead character, in this case, Antionette. She was grumpy(with reason) and not a pleasant person. Okay, no big deal. I don't know, it just didn't work on some level. The conversations all seemed too long, too involved, there was little time in the story outside of the squad room. Kind of like a one setting play. With that component, it was tedious at times. Every previous book by this author has been exceptional, with ethereal qualities you just don't get in most literature today. I was so looking forward to this book. Hoping for a better installment in the Dublin Murder Squad next time.

4 of 4 people found the following review helpful.
because I expect good things. The Trespasser did not disappoint me
By Penelope Schmitt
French is on my short list of writers whose novels I pre-order, because I expect good things. The Trespasser did not disappoint me. It was not as heart rending as Faithful Place, nor as hair-raising as Broken Harbor, but it was another excellent foray into French's great gift for creating difficult narrators, who may act as their own worst enemies, but whom we can't help rooting for and hoping for all the way, even when what we root for is comeuppance. Detective Antoinette Conway is an outsider with an outsize attitude--dark skinned, with an Irish mother and an unknown foreigner for an absconded father. As a woman working in a man's world, she assumes every man's hand is against her, and her demeanor is accordingly and unwaveringly hostile. This blind spot as big as Gibralter is of course going to make trouble for her, and does. The case she and her more personable partner, Steve Moran, must solve appears to be a common enough domestic argument gone horribly wrong. But both detectives soon get a feeling that it is not as open and shut as it seems. Really, to say much more would be to give far too much away. The pleasure and suspense of the story is in the slow discovery of the victim's character and personality, her history, the intense, tense and psychologically draining trip-wire internal politics of the detective squad and the interview room, and a long, slow-unfolding denouement that has the feeling of deep tragedy and human folly about it. The Trespasser of the title is a joker in the pack who unwittingly brings illumination and insight with him. Good show!

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• Sales Rank: #1456702 in Books
• Published on: 2015-02-02
• Original language: English
• Number of items: 1
• Dimensions: 9.21" h x .35" w x 6.14" l, .0 pounds
• Binding: Paperback
• 158 pages

About the Author
Dr. Howard is co-founder of AthenaInvest, a Greenwood Village-based SEC Registered Investment Advisor. He led the research project that resulted in Strategy Based Investing, the methodology which underlies AthenaInvest's investment approach. He oversees Athena's ongoing research, which has led to a number of industry publications and conference presentations. Dr. Howard currently serves as CEO, Director of Research, and Chief Investment Officer at Athena. Dr. Howard is a Professor Emeritus at the Reiman School of Finance, Daniels College of Business, University of Denver, where for over 30 years he taught courses and published articles in the areas of investment management and international finance. For many years he presented stock analysis seminars throughout the US for the American Association of Individual Investors, a national investment education organization headquartered in Chicago. Dr. Howard has been a guest lecturer at SDA Bocconi, Italy's leading business school and at Handelsho/jskole Syd in Denmark and was a 2004 Summer lecturer in international finance at EM Lyon in France. He consulted with a number of firms, most recently First Data Corp and Janus Capital Group, and served for 10 years on the Board of Directors for AMG National Trust Bank N.A., a financial counseling and investment management firm headquartered in Denver. After receiving his BS in Mechanical Engineering at the University of Idaho, Dr. Howard worked three years for Proctor Gamble as a production and warehouse manager. He then entered Oregon State University where he received an MS in Management Science after which he received a Ph.D. in Finance from the University of Washington.

Most helpful customer reviews

0 of 0 people found the following review helpful.
Value Investing Explained!
By Amazon Customer
A must read for amateur and professionals who seek to understand, practice and implement value investment
strategy. Beware, however, that value investing is not easy stuff and takes real work. The concept of value
investing is complex requiring focus and attention to detail.

Prof. Howard identifies the research requirements and valuation process to select and analyze undervalued stocks.
He goes into great practical and academic detail to explain and demonstrate how the process can result in intellectual
satisfaction and consistently superior investment returns.

Refreshingly fact based, his book is written in an easy comprehensible style. It's fun reading with a hint of humor and a professional glimmer of sarcasm. He also instructs the reader to be patient, ignore the "noise" of the markets and try to avoid the irrational influence of volatility on the decision making process.

0 of 0 people found the following review helpful.
Very clearly written and easy to understand
By DHeadley
This book is thorough guide for serious value investors, both professional or otherwise, but as a bonus contains a wealth of investing wisdom. Very clearly written and easy to understand, it is filled with practical observations and advice that one imagines are based on a lifetime of investing experience. These stand in sharp contrast to the output of the many financial journalists writing to fill column inches by a deadline and feeding their readers what makes them comfortable. I came away with a much better understanding of how one improves the odds of investment success, particularly by avoiding being ruled by short term emotional reactions.

0 of 0 people found the following review helpful.
ok
By PBS
not much new

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The New Value Investing: How to Apply Behavioral Finance to Stock Valuation Techniques and Build a Winning Portfolio, by C. Thomas Howard PDF
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From the peat bogs and woodlands that help to secure our water supply, to the bees and soils that produce most of the food we eat, Britain is rich in 'natural capital'. Yet we take supplies of clean water and secure food for granted, rarely considering the free work nature does for Britain. In fact for years we have damaged the systems that sustain us under the illusion that we are keeping prices down, through intensive farming, drainage of bogs, clearing forests and turning rivers into canals. As Tony Juniper's new analysis shows, however, the ways in which we meet our needs often doesn't make economic sense. Through vivid first hand accounts and inspirational examples of how the damage is being repaired, Juniper takes readers on a journey to a different Britain from the one many assume we inhabit, not a country where nature is worthless or an impediment to progress, but the real Britain, the one where we are supported by nature, wildlife and natural systems at almost every turn.

• Sales Rank: #3275270 in Books
• Published on: 2015-02-12
• Original language: English
• Number of items: 1
• Dimensions: 7.87" h x .47" w x 5.12" l, .52 pounds
• Binding: Paperback
• 288 pages

Review
Praise for Tony Juniper: 'He is by popular consent the most effective of Britain's eco-warriors Independent One of the top ten environmental figures of the last thirty years The ENDS Report [Tony Juniper] is among the 100 people who are making the decisions that affect your life Country Life What Nature Does for Britain, a fine book from Tony Juniper, demonstrates the many ways in which good management of our national natural assets promotes all kinds of economic and social benefits. It's a must-read for any one who is concerned about the way we run our country. -- Simon Barnes Independent on Sunday Partly a vision of a sustainably managed British landscape, and partly a tour of British businesses that have made a success of going green ... Juniper wants us to practise common-sense domestic economy -- James McConnachie Sunday Times Juniper provides an excellent summary of the UK's evolving ecological crisis -- James Attlee Independent Part research round-up, part manifesto, this treatise on Britain's 'natural capital' is a model of pragmatism. -- Barbara Kiser Nature Juniper's book is excellent ... no one is better qualified to tell us what is happening to our world, or what is being done and could be done to put things right. -- Colin Tudge Literary Review A cogent, persuasively argued book, Juniper shows how nature sustains us, from the peat bogs and woodlands that help to secure our water supply to the huge variety of insects that pollinate our plants. -- Eithne Farry Sunday Express Demonstrates the economic benefit of the mountains, moorland, hedgerows and wildlife that we love ... But this book isn't a diatribe. Despite climate change, Juniper doesn't take the we're-all-doomed view of the natural world. -- Clive Aslet Daily Telegraph Asks serious questions of our hopelessly myopic politicians, and suggests practical measures that would make the world a much better place. -- Stephen Moss Guardian Nature Books of the Year: If you only have time to read one book about our natural world, make it this one -- Andrew Sells, Chairman of Natural England Country Life

About the Author
Tony Juniper is an independent sustainability and environment adviser, including as Special Advisor with the Prince's Charities International Sustainability Unit and as a Senior Associate with the University of Cambridge Program for Sustainability Leadership, and he is a founder member of the Robertsbridge Group that advises international companies. He speaks and writes on many aspects of sustainability and is the author of several books, including the bestselling What Has Nature Ever Done for Us?, the award-winning Parrots of the World and How Many Light Bulbs Does It Take To Change A Planet? He was a co-author of Harmony, with HRH The Prince of Wales and Ian Skelly. He began his career as an ornithologist, working with Birdlife International. From 1990 he worked at Friends of the Earth and was the organisation's executive director from 2003-8 and was the Vice Chair of Friends of the Earth International from 2000-8. www.tonyjuniper.com, twitter:@tonyjuniper.com

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0 of 0 people found the following review helpful.
Five Stars
By A. V. Honey
exceded expectations

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Errata Notice: Sanford Guide to Antimicrobial Therapy 2016:
Print Edition Content Notices (shipped prior to 5/11/16) Antibacterial Activity Spectra (Table 4, p78):
A column shift caused activity data to be displayed incorrectly for Linezolid, Tedizolid, Rifampin (combination), TMP-SMX, Fosfomycin and Metronidazole vs. Anaerobic gram-positive bacteria (the lower right quadrant of the page). A sticker is available to replace the page:
http: //www.sanfor dguide.com/support/errata

• Sales Rank: #26555 in Books
• Published on: 2016-04-01
• Original language: English
• Dimensions: 6.90" h x .90" w x 4.20" l,
• Binding: Spiral-bound
• 254 pages

Most helpful customer reviews

3 of 3 people found the following review helpful.
Pharmacy School Rotations Lifesaver
By Kriabroo
I ordered this for my pharmacy school rotations to have on hand for those tough ID questions and dosing. This fits perfectly in my white coat pocket and even has colored pages for the charts of spectrum of coverage (different from older edition). The print also seems slightly blurred than the previous edition, although still clearly legible. Would recommend for rotations for sure!

1 of 1 people found the following review helpful.
Great item for any pharmacy/medical student
By Tabithia
Great item for any pharmacy/medical student! I used this during a hospital rotation - it saved me when I found out the Wifi was spotty and the online version could not be accessed there. I recommend familiarizing yourself with this book before you whip it out and try to be an antibiotic queen though. There is a ton of information packed in one little space that is not entirely easy to just flip to. I still give it 5 stars because the item itself is great - it is hard to categorize so much information and Sanford is great at doing so.

1 of 1 people found the following review helpful.
The best antimicrobial reference for everyday clinical use
By Marion
This book is essential when dealing with patients who have numerous allergies, and the typical antibiotics are not available to use. Labs only test for a limited number of antibiotic sensitivities, and this book gives me practical information to solve everyday challenges. My only complaint is that the print is SO SMALL IT IS NEARLY UNREADABLE. Being in my late 50s, and even using reading glasses, I struggle to read the charts and print. They should print it in a larger font.

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• Published on: 2014-12-02
• Original language: Tagalog
• Number of items: 1
• Dimensions: 8.00" h x .77" w x 5.00" l, .74 pounds
• Binding: Paperback
• 308 pages

About the Author
I'm Chabby Camaclang a.k.a chabbyworld143 on Wattpad. A beginner Wattpad Writer From the City of Imus,Cavite. Nakapagtapos ako ng college noong 2013 sa Asian Institute of Computer Studies sa kursong Computer Science at ngayon ay nagtatrabaho ako sa City Hall ng Imus. Inumpisahan kong isulat ang Teardrops on my Diary after ko mabasa ang Voiceless, I met a Jerk Who's name is Seven, She's Dating the Gangster at Diary ng Panget, na-inspired ako gumawa ng sarili kong story. Kahit na wala akong background at wala akong alam sa pagsusulat, lakas loob kong isinulat ang TOMD . At para maiba, ginawa kong bida ang isang Gay. Feeling ko kasi puro Girl/Boy love story lang ang bida sa Wattpad eh, kaya naisipan kong gumawa ng same sex Love Story to make a difference. Nakuha ko ang Title ng story sa music player ko. Nag shuffle ako ng kanta at tumigil ako sa kanta ni Taylor Swift na, Teardrops On My Guitar. Pinalitan ko lang ang Guitar ng Diary, siyempre nga dahil ang Diary ng Panget ang isa sa mga inspiration ko sa pagsusulat. Sa ngayon nasa mahigit 225,000 reads na ang TOMD sa Wattpad. At inuumpisahan ko na ring isulat ang Book 2 ng akdang ito.

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Promoting a continued and much-needed renaissance in biopharmaceutical manufacturing, this book covers the different strategies and assembles top-tier technology experts to address the challenges of antibody purification.

•�� �Updates existing topics and adds new ones that include purification of antibodies produced in novel production systems, novel separation technologies, novel antibody formats and alternative scaffolds, and strategies for ton-scale manufacturing
•�� �Presents new and updated discussions of different purification technologies, focusing on how they can address the capacity crunch in antibody purification
•�� �Emphasizes antibodies and innovative chromatography methods for processing

• Sales Rank: #1403035 in Books
• Published on: 2017-04-03
• Original language: English
• Dimensions: 9.40" h x 1.60" w x 6.30" l,
• Binding: Hardcover
• 752 pages

From the Back Cover

Stay on the cutting edge of antibody purification with the insights of industry experts

Biopharmaceutical companies are under extreme pressure to develop robust and economical large-scale processes while consistently meeting regulatory standards for safety and purity. Unfortunately, while upstream productivity has increased in line with demand, downstream processing is mired in a technology crisis resulting in production bottlenecks. Antibody purification is sandwiched between fermentation and drug formulation, two areas that have traditionally received the lion's share of industry awareness as well as generous research funding and attention in the literature. As a result, improvements in purification technology are needed urgently to meet the challenges of increasing demands without sacrificing product quality.

The second edition of Process Scale Purification of Antibodies continues the legacy of its predecessor to offer scientists, researchers, and engineers an essential resource focused on best practices in manufacturing antibody drugs. It covers different antibody purification strategies, including new developments since the publication of the first edition, and an assembly of top-tier experts in these disparate technologies with the common aim of addressing problems in process-scale antibody purification.

Recognized for providing a fresh perspective on traditional chromatography as well as alternative technologies and unit operations, the first edition covered innovative developments in protein purification like smart membranes, bioaffinity mimetics as well as orthogonal, and integrated strategies. The revision updates these topics and also introduces platform concepts that have gained traction over the ensuing years—including the purification of antibodies produced in novel production systems, novel separation technologies, novel antibody formats and alternative scaffolds, and strategies for ton-scale manufacturing.

Process Scale Purification of Antibodies, therefore, consolidates the unique niche occupied by its predecessor and maintains interest in this neglected subject area by promoting the continued, much-needed renaissance in antibody purification.

About the Author

Uwe Gottschalk, PhD,is Chief Technology Officer at Lonza Pharma/Biotech, Switzerland. Previously, he served as Group Vice President at Sartorius Stedim Biotech (2004-2014) and in various development and manufacturing capacities at Bayer Health Care (1991–2004). Dr. Gottschalk received a doctorate in chemistry from the University of M�nster (Germany) for work on antibody-drug conjugates at the Cancer Research Campaign Laboratories in Nottingham (UK). He is Head Lecturer at the University of Duisburg-Essen, Germany, and has written extensively in the areas of industrial biotechnology and somatic gene therapy.

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An Introduction to Bioinformatics introduces students to the immense power of bioinformatics as a set of scientific tools. The book explains how to access the data archives of genomes and proteins, and the kinds of questions these data and tools can answer, such as how to make inferences from data archives and how to make connections among them to derive useful and interesting predictions.

Blending factual content with many opportunities for active learning, An Introduction to Bioinformatics offers a truly reader-friendly way to get to grips with this subject, making it the ideal resource for anyone new to the field.

Features
- Strikes a careful balance between biology and computer science, introducing those aspects of computer science which underpin the subject without demanding detailed prior knowledge.
- Contains numerous learning features, including exercises, problems, and WebLems.
- Retains the eloquent style and clarity of explanation for which the author is renowned.
- An Online Resource Centre includes figures from the book available to download to facilitate lecture preparation, as well as a variety of interactive resources, including web links, 3D structures, and data sets.
ew to this Edition
- New chapter on biological organization in space and reflects recent advances in genomics, transcriptomics, proteomics, and metabolomics.
- New chapter on scientific publications and archives provides a state of the art inventory on sourcing scientific literature.
- Expanded coverage of structural bioinformatics.
- Enhanced Online Resource Centre, with new guided tours of key websites, and lab assignments to support the in-depth exploration of concepts and themes covered in the book.

• Sales Rank: #1463669 in Books
• Published on: 2008-06-02
• Ingredients: Example Ingredients
• Original language: English
• Number of items: 1
• Dimensions: 7.40" h x .80" w x 9.60" l, 2.40 pounds
• Binding: Paperback
• 474 pages

Review
`Review from previous edition I have a very favourable opinion of this book. It covers the basics of all aspects of bioinformatics at a level that is very compatible with how I teach. The amount of material presented is appropriate for a one semester class. The problems are excellent: well thought out and plentiful.' Dr Mitrick A. Johns, Northern Illinois University, USA

`I like Lesk's conceptual style. It is close to how I teach...it provides a little bit of web sites, a little bit of algorithms, a little bit of theory, and much casual exposure to a range of bioinformatics topics. It is easy to use as a text. ' Dr Lorraine Marsh, Long Island University, USA

`This is a very good introductory textbook in bioinformatics. It is well-structured and nicely laid out. There are numerous examples and problems attached to each chapter, including the novel Weblems.' Dr Karen Page, University College London, UK

`Overall the book is well laid out. There is a good mixture between information text and case studies. There is a good selection of recommended reading and problems at the end of each chapter. I like the learning goals at the beginning of each chapter and the plan of the book before chapter 1.' Dr Dawn Louise Arnold, University of the West of England, UK

About the Author
Arthur M. Lesk is Professor of Biochemistry and Molecular Biology at The Pennsylvania State University, USA.

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13 of 13 people found the following review helpful.
Excellent introduction, but a bit light
By Eric "Siggy" Scott
Lesk's introduction is an excellent guide for the newcomer to the world of large-scale genomic data. It is my opinion that you can end your search here for an entry point to the modern field of bioinformatics. It's organized around tools of the trade rather than grandiose theory (systems biology discussions left off till the last chapter), and will serve better as a introduction for undergraduates or researchers new to the field than a reference book for experts. It's biggest perk is the lucidness of discussion and readability.

As best I can tell, the target audience is undergraduate biology students who have basic familiarity with computer programming. Virtually no mathematical sophistication is required -- there is not a proof in sight, and complex mathematical topics like Hidden Markov Models and Monte Carlo algorithms are explained in an unintimidating, intuitive manner. Computer science knowledge such as graph theory, dynamic programming, and computational complexity are introduced minimally and only when they are needed.

Biological concepts are also sufficiently explained, except for perhaps a term here and there, and as a computer scientist I found the book a cinch to read.

Lesk's writing style is lucid and motivated. You know not only what you're learning, but why you're learning it and what you can do with it. Therefore, the book is self-contained and is excellent for self-study.

The first half of the book (Chapter 1-4) are a high-level overview, and a practical summary of existing databases of genetic and proteomic data. This serves an excellent guide for those who A) need to become familiar with the websites that "everybody" in the field knows about, or B) are eager to get their paws on sequence data and start playing! Chapter 3 even gives a (very) brief introduction to data mining and natural language processing for extracting information from the literature.

Chapters 5-7 are the meat of the matter. Sequence alignment (chapter 5) is "THE basic tool of bioinformatics" (p. 243), and is what much of the technical material is organized around. Dotplots, single and multiple sequence alignment, profiling, BLAST, PSI-BLAST, Hidden Markov Models, and phylogenetic trees are all discussed and situated so that the read knows the advantages and disadvantages of each tool, and their limitations used to motivated future chapters on protein structure.

Chapter 6 covers protein folding, structure prediction, classification, and function prediction, as well as applications to drug discovery.

Chapter 7 ends the book with a more theoretical, big-picture discussion of systems biology, information theory, and regulatory networks.

Overall, I think this book is great. It will give you a solid, if low-resolution understanding of the field, and the writing style ensures that you have a genuine understanding of the tools' relationship to scientific questions. The book is full of practical tips like "Visual examination of multiple sequence alignment tables is one of the most profitable activities that a molecular biologist can undertake away from the lab bench. Don't even THINK about not displaying them with different colors for amino acids of different physiochemical type" (p. 271). He also is careful to emphasize difficulties in, for instance, inferring homology from sequence similarity, and in making assumptions about mutation rate. And if you are a biologist who doesn't need more than a basic understanding of the most effective tools, maybe this is sufficient.

Perhaps best of all, you can actually *read* a book like this from cover to cover! And you will actually *remember* what you read!

That said, as a computer scientist with a math degree under my belt, I did miss the presence of rigorous mathematics. The academic field of bioinformatics is much more technical than this introduction-for-mathophobes would imply, as other books like Waterman's (now outdated) Introduction to Computational Biology: Maps, Sequences and Genomes (Chapman & Hall/CRC Interdisciplinary Statistics) makes painfully clear. Then again, that's probably why I didn't ever finish reading Waterman!

That said, I should point out that I was never bored with Lesk's description of algorithms.

1 of 1 people found the following review helpful.
Bioinformatics lite
By JoeT
If you want a really good intro to bioinformatics and don't want to (or don't know) the necessary math, then this is book for you.
Very easy read, and you will not be hit over the head with complex math.
In fact, most of the math principles are explained in a "for dummies" way, so the topic is readily accessible to everyone.
Highly recommended!

1 of 1 people found the following review helpful.
Five Stars
By Ian F.
Good intro book

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• Published on: 2014-12-08
• Binding: Paperback

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